Thu 22 Feb 2007
Future of tissue engineering in rheumatic diseases.
Posted by admin under rheumatoid arthritis
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This article looking into the connection between joint repair and rheumatic diseases is by Ringe and colleagues from Berlin. It is available in full from pubmed using the ID 17309320.
Chronic inflammation during rheumatoid arthritis and degenerative processes during osteoarthritis eventually result in joint destruction.
Anti-inflammatory therapies facilitate the inhibition or delay of progressing joint cartilage and bone loss, but do not regenerate these tissues. Surgical procedures are quite unsatisfactory in long-term evaluation and often lead to endoprothetic joint replacement. Present tissue engineering technologies offer new strategies for the treatment of cartilage and bone defects. Here, beyond implantation of cell suspensions, biomaterials combined with tissue-specific cells or mesenchymal stem cells are clinically applied. This review focuses on state-of-the-art and future in situ mesenchymal stem cell-based tissue engineering approaches for joint repair in patients with rheumatic diseases.
The full article is published in the journal expert opinion on biological therapy.
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